Expect roughly 20 questions from this section to appear on the USMLE Step 1 Medical Board Exam.

High Yield Ratings for this Section:

10 – B & T Cell Activation

9 – Toxoid Vaccines

9 – Antibody Isotypes

8 – Type I Hypersensitivity

7 – Tumor Necrosis Factor

7 – Interferon

7 – Chronic Granulomatous Disease (CGD)

6 – Prostaglandins, Leukotrienes & Bradykinin

6 – Chronic Organ Transplant Rejection

5 – Type IV Hypersensitivity

5 – Type III Hypersensitivity

5 – Scar Formation

5 – Interleukin 2

5 – DiGeorge Syndrome

4 – Live/Attenuated Vaccines

4 – Graft vs. Host

4 – Complement System

4 – Cardinal Signs of Inflammation

4 – Autoantibodies

3 – X-Linked Agammaglobinemia

3 – Transudate vs. Exudate

3 – Severe Combined Immunodeficiency

3 – Neutrophil Extravasation

3 – Killed/Inactivated Vaccines

3 – Interleukin 1

3 – Granulomas

2 – MPO Deficiency

2 – IgA Deficiency

2 – Chemotactic Factors IL-8 & LTB4

2 – Acute Organ Transplant Rejection

1 – Type II Hypersensitivity

1 – Passive vs. Active Immunization

1 – Hyperacute Organ Transplant Rejection

1 – B & T Cell Development

1 – Antibody Structure

 

No Yield:

Wiskott-Aldrich

Congenital Neutropenia

Leukocyte Adhesion Deficiency

Common Variable Immunodeficiency

Hyper IgE

IL-12 Receptor Deficiency

Ataxia Telangiectasia

IL – 3,4, 5, 6, 10, 12

HLA Subtypes

Tacrolimus

Most recombinant cytokines

Adalimumab

Rituximab

Omalizumab