Below is combined list of High Yield Ratings from all of my individual videos. Topics are listed ROUGHLY from highest to lowest importance for the USMLE Step 1 Medical Board Exam. For more information on how the HYR is determined or how it can be interpreted please see the About the High Yield Rating page. This list only includes the High Yield Rating for sections in which I have already made videos. Unfortunately, I do not yet have the HYRs for other sections because I determine the HYR as I write the material. I will update this list as I finish additional sections. This list does not include topics I rate as “No Yield”. Therefore, while the items at the bottom of this list are less likely to show up on your exam they are still worth studying.

 

Rough Estimate for the Number of Questions to Expect on the Step 1 Exam Broken Down by Section/Chapter:

20 Questions – Inflammation & Immunology Section

17 Questions – Genetics Section

13 Questions – Biochemistry Section

10 Questions – Cell Injury & Introduction to Cancer Section

8 Questions – Biostats & Epidemiology Section

7 Questions – Psychiatry Section

4 Questions – Vitamins Section

4 Questions – Doctoring Section

3 Questions – Ethics and Legal Section

 

Combined High Yield Rating by Topic:

10 –Vitamin B12 Deficiency

10 – Metastasis

10 – B & T Cell Activation

10 – Autosomal Recessive Inheritance

10 – 2×2 Tables

9 – X Linked Recessive Inheritance

9 – Toxoid Vaccines

9 – Sensitivity & Specificity

9 – Prevalence & Incidence

9 – Genetic Pedigrees

9 – Depression & Suicide

9 – Antibody Isotypes

8 – Type I Hypersensitivity

8 – Reversible vs. Irreversible Cell Injury

8 – Types of Necrosis

8 – Kartagners Syndrome

8 – Free Radicals

7 – Tumor Necrosis Factor

7 – Tay-Sachs Disease

7 – Post Transcriptional Modification

7 – Opioid Overdose & Naloxone

7 – Interferon

7 – Chronic Granulomatous Disease

7 – Cellular Adaptions

7 – Apoptosis

7 – Antidepressant Side Effects

6 – Trinucleotide Repeat Expansion

6 – DNA Translation

6 – Relative Risk and Odds Ratio

6 – p-Value and Statistical Significance

6 – Prostaglandins, Leukotrienes & Bradykinin

6 – Positive & Negative Predictive Value

6 – Cohort Study Design

6 – Chronic Organ Transplant Rejection

6 – Antipsychotic Side Effects

5 – Type IV Hypersensitivity

5 – Type III Hypersensitivity

5 – Tuberous Sclerosis

5 – Schizoid Personality

5 – Scar Formation

5 – Mitochondrial Inheritance

5 – Interleukin 2

5 – I Cell Disease

5 – DiGeorge Syndrome

5 – Cell Cycle

5 – Amyloidosis

4 – Thiamine Deficiency

4 – Standard Deviation

4 – Randomized Control Trial

4 – p53 Tumor Suppressor

4 – Osteogenesis Imperfecta

4 – Live/Attenuated Vaccines

4 – Lesch Nyhan Syndrome

4 – Graft vs. Host

4 – Epigenetics

4 – Confidence Intervals

4 – Complement System

4 – Measures of Central Tendency

4 – Case-Control Study Design

4 – Cardinal Signs of Inflammation

4 – Bereavement/Grief

4 – Benzo Indications

4 – Autosomal Dominant Inheritance

4 – Autoantibodies

4 – Alcohol Withdrawal/DTs

3 – X-Linked Agammaglobinemia

3 – Vitamin C Deficiency

3 – Vitamin B6

3 – Vitamin A

3 – Transudate vs. Exudate

3 – Mechanism of Stimulant Drugs of Abuse

3 – Statistical Hypothesis Testing

3 – Somatization

3 – Signs and Complications of Stimulant Intoxication

3 – Severe Combined Immunodeficiency

3 – Schizophrenia

3 – Randomization

3 – Polygenic Inheritance

3 – Phenylketonuria

3 – Opioid Withdrawal

3 – Niacin

3 – Neutrophil Extravasation

3 – Neurofibromatosis

3 – Mood Stabilizer Side Effects

3 – Methanol Poisoning

3 – Marfan Syndrome

3 – Killed/Inactivated Vaccines

3 – Interleukin 1

3 – Imprinting, Angleman & Prader-Willi

3 – Histrionic Personality

3 – Granulomas

3 – Folate Deficiency

3 – Down Syndrome

3 – DNA Replication

3 – Cytoskeleton Basics

3 – Collagen and Elastin Basics

3 – Borderline Personality

3 – Benzo Overdose

3 – Bcl-2 Oncogene

2- Mosaicism

2 – Von Gierkes Disease

2 – Von  Hippel-Lindau Disease

2 – Variable Expressivity

2 – Sampling & Selection Bias

2 – rb Tumor Suppressor

2 – Statistical Power

2 – Pleiotropy

2 – Number Needed to Treat/Harm

2 – MYC Oncogene

2 – MPO Deficiency

2 – Mood Stabilizer Indications

2 – McCardles Disease

2 – Incomplete Penetrance

2 – IgA Deficiency

2 – Hallucinogen Abuse

2 – Generalized Anxiety Disorder

2 – Gaucher Disease

2 – Galactose Disorder

2 – Fructose Disorder

2 – Ehlers Danlos

2 – Interleukin-8 and Leukotriene B4

2 – Chediak Higashi

2 – Case Fatality Rate

2 – Bipolar Disorder

2 – Benzo Mechanism of Action

2 – Antisocial Personality

2 – Antipsychotic Mechanism

2 – Antipsychotic Indications

2 – Antidepressant Mechanism

2 – Alcohol Metabolism

2 – Acute Organ Transplant Rejection

1 – Type II Hypersensitivity

1 – Sorbitol

1 – PTSD

1 – Passive vs. Active Immunization

1 – OTC Deficiency

1 – Nieman-Pick

1 – Maple Syrup Urine Disease

1 – Malingering

1 – Hyperacute Organ Transplant Rejection

1 – Hurler

1 – HER2/Neu Oncogene

1 – Factitious Disorder

1 – Fabry

1 – E6 & E7 Oncogenes

1 – Dependent Personality

1 – Buspirone

1 – Bulimia Nervosa

1 – BRCA 1 & 2 Tumor Suppressor

1 – Blinding & Placebo

1 – B & T Cell Development

1 – Avoidant Personality

1 – Antidepressant Indications

1 – Antibody Structure

1 – Anorexia Nervosa

1 – Absolute Risk Reduction and Attributable Risk